Cam Newton completed 23 of 33 passes for 303 yards, a touchdown and an interception, but lost to Tampa Bay 16-10.
Nick Fairley had his second career sack for Detroit against St. Louis and finished with two quarterback hits on Sam Bradford.
Jerraud Powers was named the starting cornerback for the rebuilding Indianapolis Colts, and he responded with six solo tackles, one tackle for a loss and two passes deflected.
Tennessee Titans kicker Rob Bironas connected on both field goal attempts from 24 and 28 yards as well as an extra point.
Former Thorpe Award recipient Carlos Rogers is coming off a Pro Bowl season for the San Francisco 49ers and began his 2012 campaign with four solo tackles and a sack.
Minnesota Vikings wide receiver Devin Aromashodu caught all three passes thrown to him and ended the game with 61 yards receiving with a long of 26 yards.
Running backs Ronnie Brown of San Diego and Ben Tate of the Houston Texans saw limited action in the first week.
Brown finished with five rushes for five yards, but caught all five passes thrown his way for 26 receiving yards. Tate had similar numbers and posted 28 yards on eight touches.
Miami Dolphins linebacker Karlos Dansby had nine tackles, six solo and one for a loss, in Miami’s loss to Houston.
Four former Tigers are out for the season. Running backs Tristan Davis and Mario Fannin (knee) and offensive linemen Brandon Mosley (ankle) and Lee Ziemba (knee) have been placed on injured reserve.